Roger Detels, M.D., M.S.

Professor of Epidemiology and Medicine

Dr. Detels is the director of the Los Angeles Center of the Multicenter AIDS Cohort Study which has been in existence since 1984. The total number of participants in the Los Angeles Center is 2,000 MSM and for the entire MACS over 6,000 men. Over 900 papers on various aspects of the natural history at the epidemiologic, clinical and molecular level have been published by the MACS. Professor Detels’ primary interest is in identifying factors associated with resistance to infection including genetic and molecular factors, and he and his colleagues were the first to document resistance to infection. Professor Detels is also interested in factors which are responsible for long term survival of men with less than 50 CD4+ cells. He and his colleagues are currently assessing the role of the innate immune system in long term survival with low levels of CD4+ cells.  Professor Detels is also the Director of the UCLA/Fogarty AIDS International Training and Research Program, which has trained over 100 predoctoral and postdoctoral trainees from China, India, Southeast Asia, Angola and Mozambique. His research in these countries focuses on identifying factors associated with transmission of HIV and developing and evaluating intervention strategies to prevent further spread of the virus. Professor Detels has published over 300 papers of which approximately 100 have been on HIV/AIDS.

 Selected Recent Publications

Martin MP, Gao X, Lee JH, Nelson G, Wilson M, Detels R, Goedert JJ, Buchbinder S, Hoots K, Vlahov D, Trowsdale J, O'Brien SJ, Carrington M. Epistatic interaction between KIR3DS1 and HLA-B delays the progression to AIDS. Nat Genet 2002;31:429-434.

 Yang OO, Boscardin WJ, Matud J, Hausner MA, Hutlin LE, Hutlin PM, Shih R, Ferbas J, Siegal FP, Shodell M, Shearer G, Grene E, Carrington M, O'Brien S, Price CB, Detels R, Jamieson BD, Giorgi JV. Immunologic profile of highly-exposed yet HIV-1 seronegative men. AIDS Res Hum Retroviruses 2002;18(14):1051-1065.

 Giorgi JV, Lyles RH, Hultin LE, Yamashita TE, Mellors JW, Matud JL, Jamieson BD, Margolick JB, Rinaldo CR, Phair JP, Detels R, Muñoz, A. Relative predictive value of immununologic and virologic markers after long or short duration of human immunodeficiency virus type 1 infection.  J Acquir DeficSyndr 2002;29-346-355.

 Phair JP, Mellors JW, Detels R, Margolick JB, Muñoz, A. Virologic and immunologic values allowing safe deferral of antiretroviral therapy. AIDS 2002;16(18):2455-2459.

Gange SJ, Lau B, Phair J, Riddler SA, Detels R, Margolick JB.  Rapid declines in total lymphocyte count and hemoglobin in HIV infection begin at CD4 lymphocyte counts that justify antiretroviral therapy.  AIDS2003;17(1):119-121.

Ahdieh-Grant L, Yamashita TE, Phair JP, Detels R, Wolinsky SM, Margolick JB, Rinaldo CR, Jacobson LP. When to initiate highly active antiretroviral therapy: a cohort approach.  Am J Epidemiol 2003;157(8):738-746.

Liu C, Carrington M, Kaslow RA, Gao X, Rinaldo CR, Jacobson LP, Margolick JB, Phair J, O'Brien SJ, Detels R. Association of polymorphisms in human leukocyte antigen class I and transporter associated with antigen processing genes with resistance to human immunodeficiency virus type 1 infection.  J Infect Dis 2003;187(9):1404-1410.

Dorak MT, Tang J, Tang S, Penman-Aguilar A, Coutinho RA, Goedert JJ, Detels R, Kaslow RA. Influence of human leukocyte antigen-B22 alleles on the course of human immunodeficiency virus type 1 infection in three cohorts of white men.  J Infect Dis 2003;188:856-863.

 Cole SR, Hernán MA, Robins JM, Anastos K, Chmiel J, Detels R, Ervin C, Feldman J, Greenblatt R, Kingsley L, Lai, S, Young M, Cohen M,  Muñoz A. Effect of highly active antiretroviral therapy on time to acquired immunodeficiency syndrome or death using marginal structural models.  Am J Epidemiol 2003;158(7):687-694.

 Lau B, Gange SJ, Phair J, Riddler SA, Detels R, Margolick JB.  Rapid declines in total lymphocyte counts and hemoglobin concentration prior to AIDS among HIV-1-infected men.  AIDS 2003;17(14):2035-2044.

 Modi WS, Goedert JJ, Strathdee S, Buchbinder S, Detels R, Donfield S, O'Brien SJ, Winkler C. MCP-1 - MCP-3 - eotaxin gene cluster influences HIV-1 transmission.  AIDS 2003; 17:2357-2365.

 Breen EC, Boscardin WJ, Detels R, Jacobson LP, Smith MW, O'Brien SJ, Chmiel JS, Rinaldo CR, Lai S, Martinez-Maza O.  Non-Hodgkin's B cell lymphoma in persons with acquired immunodeficiency syndrome is associated with increased serum levels of IL10, or the IL10 promoter -592 C/C genotype. Clin Immunol 2003; 109(2):119-129.

 Silverberg MJ, Smith MW, Chmiel JS, Detels R, Margolick JB, Rinaldo CR, O'Brien SJ, Munoz A. Fraction of cases of acquired immunodeficiency syndrome prevented by the interactions of identified restriction gene variants. Am J Epidemiol 2004; 159(3):232-241.

 Kleeberger C, Buechner J, Palella F, Detels R, Riddler S, Godfrey R, Jacobson L. Changes in adherence to HAART medications in the multicenter AIDS cohort study.  AIDS 2004; 18:683-688.

 Killian MS, Matud J, Hausner MA, Gregersen PK, Giorgi JV, Monteiro J, Hultin LE, Yang OO, Detels R, Jamieson BD.  Persistent alterations in the T-cell repertoires of HIV-1 infected and at-risk uninfected men.  AIDS 2004; 18(2):161-170.